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Plexus Probio5 Side Effects: Is this Probiotic Safe to Use?

The awareness for better health and wellness among individuals is growing day by day. Along with it, the health issues are also taken care of by several dietary supplements in the market these days.

Plexus Probio5 is another dietary supplement for improving your overall health and wellness. The supplement claims to achieve the health goals by bringing positive enhancement to your digestive system

The probiotic supplement contains five beneficial bacterial strains that promote friendly bacteria in your digestive system. It also says to help with issues like diarrhea and constipation.

But, Plexus Probio5 might come with certain side effects you are unaware of. In today’s article, we tried explaining almost everything about the side effects Plexus Probio5 may carry.

With that being said, let’s dive in.

What is Plexus Probio5?

Plexus Probio5 is a probiotic supplement manufactured by Plexus worldwide which is similar to Gut Connect 365 and Provitalize. Also, this supplement is formulated to promote overall digestive system health along with helping you in supporting a proper yeast balance in your gut.

Note: Don’t know what a Probiotic is? These are live microbial supplements claimed to provide health benefits by producing vitamins, maintaining microbial flora, and enhancing the mucosal immune system. Mostly they achieve it by improving and restoring your gut flora.

The Plexus Probio5 formula contains a unique blend of probiotics and enzymes that claims to improve digestive health and help in the breakdown of protein and fibrous foods in one’s body. Thanks to the enzymes present in it.

The above benefits claimed by Plexus worldwide come from the five beneficial probiotics which include Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus Plantarum, and Saccharomyces boulardii. Each is capable of delivering 2 billion colony-forming units (CFU) per capsule. 

Plexus Probio5 Possible Side Effects

Girl experiencing side after using supplement
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Besides many health benefits and successful clinical trials of the ingredients present in this supplement, some users did face common side effects using the Plexus Probio5 supplement. These are just common side effects that come with any probiotic supplements.

Generally, probiotic supplements are safe for most people because these good bacteria are already present in our body, and thus they help increase their numbers. But people who are consistently having bloating/constipation or gastrointestinal disorders must consult their doctor before using Plexus Probio5.

Few commonly mild side effects attached to Plexus Probio5 probiotic supplement include:

  • Indigestion and constipation.
  • Nausea and Dizziness.
  • Gas and bloating.
  • Increases the thirst
  • Diarrhea.

You will especially face or experience these above side effects/ symptoms in the first few days of using it. And as mentioned these side effects are typically mild and go away after your body gets used to the probiotic.

Aside from the presence of ingredient probiotics, enzymes, and vitamins, this supplement also contains brown rice powder, gelatin, and yeast as other ingredients. These may even cause allergic reactions to the folks who are allergic to any one of these 3 ingredients.

A recent study on probiotic supplements found that long-term uses of probiotic supplements lead to poor intolerance to acids and bile salts and long-standing issues of antibiotic-resistant.

Also in rare cases, probiotic supplements generally in which bacteria or yeast are found can increase the risks of infections in some individuals (7,8,9). 

Here’s what some Plexus Probio5 supplement users said about its side effects: 

“When I had zero digestive problems. Plexus gave me MAJOR digestive problems. Horrible constipation, and bowel blockage. Hemroids and anal fissures. My stomach now refuses to digest 98%of food. This has been going on for 6 months and I can’t fix it. I’m so distraught. I was healthy before plexus. I only took the plexus for 3 weeks”– Shelly.

“I took this and 3 other products by plexus and within a week I was having migraines, vertigo, stomach cramping, fast heartbeat, diarrhea, extreme dehydration even though I was drinking water like tomorrow! They will lie and say it is your body cleansing itself but it has been like this after a week of stopping and still not myself!!”– Billie Arens.

“This Probiotics contains YEAST. If you are allergic to yeast be careful as I had a serious allergic reaction. It is not noted in the product description and I was completely disappointed to find it had items I was allergic to in it. Even when I called a rep from Plexus, they said the yeast is for digestive reasons, however, being allergic, NO YEAST is in probiotics, which is what all this product tries to replicate”– Larisa.

Check: Provitalize Side Effects: Is the Probiotic Supplement Effective?

What Ingredients Does Plexus Probio5 Contain?

Plexus Pro Bio 5 Supplment facts/Nutrtion Label
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Plexus Probio5 is made from a blend of probiotics and enzymes and these enzyme blends are able to help you to keep your intestinal yeast in balance and support a healthy intestinal tract.

Enzyme blends in Plexus Probio5 include serrapeptase, cellulase, chitosanase, and proteases. These probiotics promote the growth and presence of healthy bacteria counts and maintain pH levels in your gut.

Another main ingredient in this dietary supplement is probiotics that act as protectants for your intestines and also help you to fix and improve many common digestive discomforts like bloating gas, and constipation.

And the name of these five vital Probiotics blends in Plexus Probio5 includes Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus Plantarum, Bacillus coagulans, and Saccharomyces boulardii.

ingredients include:

  1. Bacillus Coagulans
  2. Bifidobacterium Longum
  3. Lactobacillus Acidophilus
  4. Lactobacillus Plantarum
  5. Saccharomyces Boulardii
  6. Enzymatic Blend (proteases, chitosanase, cellulase, serrapeptase),
  7. Vitamin C
  8. Vitamin B6,
  9. Grape Seed Extract

Warning and Doses for Plexus Probio5


Plexus Probio5 supplement recommended dose is to take 4 capsules initially at bedtime. Specifically for adults, it’s 1 capsule daily at bedtime.

In this way taking these capsules in the right amount will provide you beneficial effects and may fulfill your expectations.

Below you can see their label image on the suggested usage and serving size per capsule and serving per container/bottle.


Before taking any dietary supplement, consulting with your doctor should always be your first priority. This helps you ensure the safety of the supplement. Also, it saves you from the side effects and allergic reactions beforehand.

For certain people in a few circumstances, this supplement might affect your health and you should completely avoid Plexus Probio5 in such a situation. Read below: 

  • Do not take them without the doctor’s prescriptions.
  • Teenage or children with less than 18 yrs of age and toddlers.
  • Nursing mothers and pregnant ladies.

Also, do not take this supplement if you’re in any serious medical condition. In such cases simply avoid this supplement or talk to your practitioner about it if you want to consume it anyhow.

Do not exceed the recommended dose on the label, which is 2-4 capsules per day as it can help to reduce the side effects. 

Important Note: Please make sure to read the instructions and warnings on the product label and apply those rules to your routine.

Does Plexus Probio5 Have any Benefits?

The range of effective probiotics and enzymes ingredients present in Plexus Probio5 can provide benefits for your gut health. These ingredients have numerous health benefits for your body in the long run.

Benefits of Plexus Probio5 Probiotics Supplement Include:

  • It also promotes the growth and presence of healthy bacteria counts and maintains pH levels in your gut.
  • It is able to help you to keep your intestinal yeast in balance and support a healthy intestinal tract.
  • Supports healthy digestion and regulates the functioning of the entire digestive system. 
  • It could actually help to improve the natural response to imbalance
  • The active probiotics in this supplement act as protectants for your intestines.
  • It contains high sources of antioxidants.
  • Can help to make your digestion process fast and effective over time.
  • Helps to dissolve nutrients quicker and produce more energy.
  • Improve the functioning of the immune system because of vitamin c.

These are some of the benefits and claims made by the Plexus Probio5 supplement in their official stores. Also, it’s beneficial for people who regularly suffer from colon problems or experience digestive system discomfort.

Check: Shakeology Side Effects: Is this Superfood Shake Worth the Price?

Customer Review Of Plexus Probio5

On Amazon, people rated Plexus Probio5 4.6 out of 5, with an overall satisfaction rate of 87% which is a lot for a probiotics supplement like this. And on its official stores, there is no reviews and rating section of this supplement, which is disappointing.

A common complaint is that the product does not work or the user doesn’t see any difference in taking Plexus Probio5.

Reviews of Plexus Probio5 were positive whether it’s on Amazon or Influenster. While most of the reviewers praised this probiotics supplement, a few negative reviews also said it doesn’t work, the price is too high and some common product quality issues. Wanna listen to what they say? Here you go.

Let’s look at some positive ones and critical reviews of customers already using it.  

“Love this probiotic! It has definitely helped me with my GI issues And it also helps me to sleep so well. If you are looking for a good probiotic I would highly suggest this one” – Nicole W.

“Absolutely love this product! Since taken regularly I rarely get any yeast infections any more. Can’t live without this! No improvements are needed. Price is good considering the benefits. That outweighs the price point. Again, ABSOLUTELY love this product. Will recommend it to anyone”– Sonya W.

“Have taken for 3 days. Only taking two at bedtime. Was afraid to take in the a.m. and p.m. so thought I’d see if it worked just by taking it at bedtime. So far so good. Those of us with IBS know how important it is to go every day. The struggle continues but so far I’m pleased”– Patrick M Mink.

“I found these to be beneficial, just too pricey! A friend actually sent me an order when she signed on, in hopes that I would want to sign on as well. I just can’t see paying that much for something I can get otc and so much less close to home. I have found other ways to maintain gut health, etc” – Mindy R.

“I don’t believe I received the actual Plexus ProBio 5 product in the bottle. It was not like the capsules received directly from a consultant. Sent back…got a refund” – Debra Dias.

Plexus Probio5 Side Effects: Final Thought

The supplement Plexus Probio5 as a Probiotic may help you with problems like GI, gut health and improve yeast infection issues. But at the same time Plexus Probio5 was seen to show side effects like constipation and irregular bowel movement in a few cases.

Also, few users reported Plexus Probio5 to give bad stomach cramps along with making them dehydrated. But not to forget, these were only a few cases like 5-10% rest seem satisfied with the product. So giving it a try might not be that riskier as you think.

That was our take on Plexus Probio5 side effects. What’s your opinion? Ever faced any issue with a probiotic? Let us know down in the comment section.

About the Author

Purushottam is the founder and content writer at Health On Planet, a place where regular health enthusiasts visit to get honest reviews about the supplement. He has been reviewing popular dietary supplements with his years of expertise in the wellness industry. You can always trust his expertise on supplements to help you make informed choices.

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