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OneSkin Review: Is It Good For Skin Rejuvenation and Longevity?

Everyone ages, whether you’re in your late twenties or in your forties. some people believe that embracing age with grace and elegance means avoiding anti-aging skincare products.  

But sometimes while you look in the mirror, you must be wondering how can you look younger.

Feeling like you’re aging too quickly can be overwhelming, so you might be looking for a product that promises firmer, stronger, smoother, and healthier skin.

OneSkin (OS -01) can improve your skin’s health at the molecular level by combating aging from within. It is the first topical supplement to reinvent your aging process through the use of seven unique key ingredients that target the root cause of skin aging.

We thoroughly examined this skin aging supplement to help you decide whether their innovative product formulations or skincare approaches are appropriate for you.

This OneSkin review will provide you with information and statistics about the ingredients, their side effects, pros and cons, how they work, and much more.

Without further ado, let’s get started on this review.

What is OneSkin?

OneSkin is an emerging skincare topical product that is designed in order to provide you with stronger, smoother, and firmer-looking skin. 

Instead of making a supplement that cures aging and has anti-aging effects, OneSkin is promoted to reinvent aging. 

OneSkin instead of calling itself a skincare company likes being called a skin longevity brand. 

It claims itself to be the first-ever topical supplement that extends your skin health from within on a molecular level.

They have named their proprietary ingredient as OS-01 which is made up of blending seven key ingredients. The ingredients are proposed for benefits like boosting moisture content, reinforcing barrier function, and diminishing stress on your skin. 

The first look at the official website of OneSkin is pretty impressive and quite informative for someone who is seeking to understand the product. 

OneSkin Manufacturer

Mostly we find companies directly coming up without any motive and putting up their skincare product for sale. But, OneSkin is different. They have their story. 

OneSkin was developed by a team of 4 scientists who were passionate about finding a solution to prolong human healthspan. It is based in San Fransisco, Canada.

The special thing about the creation was all four scientists were females and Ph.D. holders. 

OneSkin provides two main products i.e. OS-01 Face and OS-01 Body. You can either get them on a subscription or a one-time purchase. They even write blogs on different topics.

Overall, OneSkin has a lot of resources on its official websites like reference lab, their scientific publications, events, glossary, and more, building a strong base.

What Are The Benefits Of Using OneSkin?

The OS-01 proprietary blend made using a combination of seven power ingredients helps OneSkin show noticeable benefits for your skin health. 

OS-01 reduces the accumulation of damaged skin cells to prevent the formation of dark spots, reducing skin resilience, and wrinkle formation.

OneSkin was found to benefit users’ skin in several ways during a 12-week clinical study. The benefits of OneSkin reported after the study include:

  1. OS-01 Improved skin barrier
  2. It also Improved skin elasticity 
  3. Makes your skin even, radiant, and firm
  4. Reduces the appearance of fine lines and wrinkles
  5. Improves the appearance of fine lines and wrinkles

Most of the benefits were noticed in more than 90% of the subjects indicating that there are high chances you may experience them.

However, every individual is unique, and thus the benefits of OneSkin may vary. 

Explore: Sole Youth Review: Is The SkinCare Product Legit Or Scam?

OneSkin Ingredients Evaluation

While evaluating the ingredients in OneSkin, we noticed it contains a large number of ingredients without any information on the dosage used. 

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Ingredients In OneSkin OS-01 (Source: Oneskin. co)

Even though it contains so many ingredients, the OS-01 mainly works only on the seven key ingredients. 

The seven ingredients are carefully selected in order to provide your skin with the most needed skin rejuvenation and longevity benefits. 

The key ingredients as a part of OneSkin’s innovative product formulation include:

1. OS-01 Peptide

As mentioned, OS-01 peptide is a part of the product as it will help prevent the accumulation of dead as well as aged skin cells. 

Alongside the peptide may support your DNA repair capacity, strengthen your skin barrier function, and support the epidermal thickness.

As per the resource page from reference labs it says, the OS-01 peptide was developed after screening almost 1,000 peptides. 

2. Pracaxi Oil

It is extracted from the seeds of the Pracaxi tree and is often hailed as liquid gold. Pracaxi oil is vitamin-rich and is immensely beneficial to your hair. 

Pracaxi oil is known to hydrate or moisturize your hair, promoting hair growth and strengthening damaged hair.  

OneSkin has included the Pracaxi oil in OS-01 due to its antioxidant, anti-inflammatory, antibacterial, and antifungal properties. Along with hairs, Pracaxi oil also has a regenerative and softening potential for your skin. 

3. Andiroba Oil

This oil is known commonly for its mosquito-repellent properties and is extracted from the Andiroba seeds. 

Andiroba oil has anti-inflammatory potential due to which it finds its use in conditions like swelling, muscle and joint aches, arthritis, rashes, injuries, and wounds. 

OneSkin uses it as a part of its OS-01 formula due to its property of collagen synthesis. In fact, during one 2018 study, Andiroba Oil was actually shown to promote collagen synthesis.

4. Niacinamide

Vitamin B-3 or niacinamide is one of those ingredients you can find commonly being used in any skincare supplement like Musely Spot Cream. Also, OneSkin has it. 

One of the main purposes for which it is included in OneSkin OS-01 is its moisturizing property. Besides it also provides OneSkin with antifungal, anti-bacterial, and anti-inflammatory properties.

Several studies (1,2,3) have demonstrated that Niacinamide can improve your skin structure, soothe wrinkles and fine lines, improve epidermal barrier function, and provide several other benefits. 

5. Oleic Pau Mulato Extract

Extracted from the bark of the Pau Mulato tree, it has antioxidant properties and is also known to reduce inflammation. This one is a unique ingredient in OneSkin OS-01. 

It is used in the OneSkin topical supplement since it has the property of healing skin abrasion as well as smoothing wrinkles. 

A recent study on the Pau Mulato extract showed that it is beneficial in the promotion of longevity and the modulation of age-related markers. The extract was able to enhance stress resistance and extend skin lifespan. 

6. Allantoin

It is extracted from the comfrey plant and is used for moisturizing and soothing irritation in your skin.

Allantoin can be found in skincare products because it helps to reduce skin irritation and has the ability to prevent moisture lock (4).

Researchers discovered that combining aluminum dihydroxy allantoin with skin care products can aid in the reduction of skin scarring and irritation. Nonetheless, there is little evidence to support the claim that it aids in acne and wound healing(5, 6).

7. Hyaluronic Acid

It is a naturally occurring compound in the body. Hyaluronic acid helps to bind water to collagen in the skin, making it appear plumper and more hydrated. 

Hyaluronic acid is a compound that may brighten skin and promote collagen production in order to maintain healthy skin (7).

People lose collagen and hyaluronic acid as they age, which can result in duller, dried skin. OneSkin’s use of Hyaluronic acid has shown promising research that it may help improve the appearance of your skin and prevent skin aging.

One study found that using Hyaluronic acid-containing products showed promising results for skin tightness, elasticity, and wrinkle reduction.

Final Words

An overview of the key ingredients used in making OneSkin OS-01 topical cream shows that the individual ingredients are powerful. However, the amounts specific ingredients were found missing.

The ingredients in the products had science-based evidence to help your skin with benefits such as moisturizing, longevity, skin rejuvenation, and reducing aging signs.

How Does OneSkin Work?

Now since you already know about the ingredients of the OneSkin Topical product, you might ask how it works.

The OneSkin OS-01 as you know doesn’t promote itself as an anti-aging product but as a product that promotes skin rejuvenation and longevity. 

It intends to extend your skin life on a molecular level. The OS-01 proprietary formula tends to prevent aged cell accumulation and support DNA repair. 

Alongside, ingredients like Andiroba oil are scientifically proven to promote collagen synthesis. Collagen as you know is the most abundant protein in your body and can enhance your skin’s appearance by increasing its elasticity, strength, and hydration. 

Niacinamide and hyaluronic acid are great additions as they both are known to moisturize your skin and keep it hydrated. 

Overall since the ingredients are mostly concerned with your skin rejuvenation and providing longevity to it, OneSkin might show impressive results. 

OneSkin Potential Side Effects

When taken in proper dosages, the ingredients in OneSkin are generally safe; side effects may occur, but only rarely.

A few possible side effects of OneSkin active ingredients to be aware of.

Excessive use of the Pracaxi oil can cause allergic reactions, so if you’re sensitive to it, perform a patch test before using it.

Although niacinamide may be safe to apply to the skin, niacinamide cream may cause mild burning, redness, and itching.

Reported side effects and risks of allantoin include dryness, itching, hives, redness, discoloration, and inflammation.

This supplement contains hyaluronic acid, which is usually well tolerated and likely safe when used in appropriate amounts. Allergic reactions are possible, but they are uncommon.

To ensure quality and safety, the brand’s products are subjected to third-party testing.

Otherwise, there isn’t enough reliable information on the remaining active ingredients, so consult your doctor before beginning any new supplement, including OneSkin.

In addition, if you are pregnant or breastfeeding, you should show the ingredients list to a doctor or healthcare provider to confirm safety before using the product, as stated on their product page.

Aside from that, OS-O1 FACE was tested for human sensitization to assess skin irritation and various other toxicity tests, and no adverse side effects were reported, according to the company’s product page.

Explore: Introstem Review: Does Their Skincare Product Work Or Scam?

How To Use OneSkin For Best Results?

To apply OneSkin to your face, neck, and hands, simply follow these two steps:

  1. On a daily basis, apply 1-2 pumps of OneSkin to your skin.
  2. After cleansing, only use one skin at a time in the morning and evening.

One Skin Before And After Images

Users saw dramatic results in improvement of their skin texture on using One Skin products. Here are some photos of before and after using OneSkin.

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Effect On Wrinkles Before And After Using OneSkin (Source:
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12 Weeks Result Of OneSkin Before And After (Source: oneskin. co)

OneSkin: Pros And Cons


  • May support skin health and appearance.
  • The majority of the ingredients have been shown to benefit skin health.
  • Money-back guarantee for 30 days.
  • OneSkin provides a refillable package that is easy to refill and saves you from collecting its packaging waste.
  • The product is clean, cruelty-free, and vegan-friendly.
  • It has a long shelf life of 24 months and the packaging is 100% recyclable. 


  • Contain a proprietary blend without the exact amount of each ingredient.
  • It is expensive for most middle-class individuals. 
  • Not available across popular retailers like Amazon and many more.
  • Potential for side effects and allergic reactions.

Cost And Where To Buy

OneSkin can only be purchased from the official OneSkin website or the manufacturer’s website.

OneSkin costs $120 for a one-time purchase and lasts about 2-3 months when used as directed.

When you sign up for the company’s monthly subscription and save the program, you can save 17.5 percent on a 50ml bottle of OS -01. Furthermore, they currently only ship to the United States and Canada.

Their subscription program is available either for 30 days, 60 days, or 90 days. You can choose based on your needs when you have to get it.

OneSkin’s website provides a 30-day money-back guarantee for returning products for refunds minus shipping costs. The return policy and contact information are easily accessible on their official website or in stores.

OneSkin is an extremely expensive anti-aging skin care product, with most alternatives costing between $20 and $50 for a 30-day supply.

OneSkin Reviews: What Users Think?

A YouTube creator named Penn Smith shared her experience using Oneskin for stronger, smoother, and firmer-looking skin. 

On its product page, the brand has thousands of positive reviews. OneSkin (OS-O1 FACE) has received over 800+ star reviews in its review section, and 98 percent of reviewers would recommend this product for quality and feel-good factors.

The majority of customer reviews are positive, with many praising the product for offering solutions that work for them. Although it is not available in retail stores, you can read the reviews on their official website.

One thing to keep in mind is that sometimes reviews on the company website’s product page are misleading, so don’t base your purchase decision on them.

Here are some positive and negative reviews of OneSkin:

Kristin C. says –  I recommend this product

“I’ve only been using OS for a couple of weeks and my skin looks so much better! My skin is smooth and soft and the lines and wrinkles seem to fade after applying. I’m going to continue using this product!”

Elaine A. says 

“I used to have perennially dry facial skin soon after applying moisturizer. Now my skin feels smooth and firm and glows with health. I no longer need day and night creams, just OS-O1 and sunblock”

Liza F says.

“makes my skin soft and hasn’t been drying out”

Shirley G. says 

“It’s too soon to say. It’s been almost 1 month. No changes yet that I can see. I am willing to give it more time”

Should You Buy OneSkin? The Verdict

OneSkin is undoubtedly a very carefully designed topical supplement or product for your skin. Also, it is developed by a team of passionate scientists. 

Most key ingredients are backed by scientific evidence to show results. The product has the potential to rejuvenate your skin and provide longevity to it along with helping your skin with aging. 

OneSkin can reduce wrinkles, moisturize skin, and improve skin barrier function. It can improve your skin structure, and texture and make it more smooth. 

However, the thing that concerns us the most is its price. It’s way too expensive for most folks. Each month you’ll need to pay around $100 for the subscription. 

If you can afford that much, you should surely give it a shot. And if you are not satisfied you can go for their 30-day money-back guarantee. 

That was all for the OneSkin OS-01 review. Now we would like to collect your opinion regarding the same. What do you think of OneSkin? Let us know.



About the Author

Purushottam is the founder and content writer at Health On Planet, a place where regular health enthusiasts visit to get honest reviews about the supplement. He has been reviewing popular dietary supplements with his years of expertise in the wellness industry. You can always trust his expertise on supplements to help you make informed choices.

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