What You Need to Know About the Nucific Bio X4 Side Effects

Bio X4 is a gut health and weight loss supplement that claims to improve digestive health, support weight loss, and boost energy and metabolism.

This premium formula combines four proprietary blends to address conditions such as craving control, digestive health, weight management, and increased metabolism.

Without any further ado, let’s get started.

What is Bio X4?

Bio X4 is a probiotic supplement from the company named Nucific that is designed to help you healthily lose some. 

The supplement uses a blend of Green Tea extract, Caralluma Fimbriata, digestive enzymes, and 5 highly potent probiotic strains. 

Nucific Bio X4 can promote effective weight management that works by optimizing your digestive health inside out. 

The recommended dose for having Nucific Bio X4 is taking one capsule with each meal. Its unique blend helps your body in four ways:

  1. Manages your cravings for junk foods.
  2. Boosts up your metabolism to help weight management. 
  3. Enhances digestion making it more smoother.
  4. Increases nutrient absorption by the body.

Bio X4 is designed by Dr. Amy Lee who is a board-certified bariatric physician in internal medicine. 

The company is based in California. However, the price point of Nucific Bio X4 is quite high and so it may be expensive for some users.  

Bio X4 Potential Side Effects

Nucific Bio X4 ingredients are mostly taken from natural sources like the Digestive enzyme, Green tea extract, and Probiotics. Thus, most likely it should not cause any side effects in healthy individuals (1).

Green Tea extract used in Bio X4 which can be useful for increasing your metabolism and promoting weight loss can have some side effects. 

Due to its caffeine content, green tea extract might show irritability, anxiety, and sleeplessness. However, the side effects are not very common.

Probiotics like Lactobacillus acidophilus are generally safe but can sometimes lead to side effects like dizziness, itching, rashes, troubled breathing, and unusual weakness. 

Lactobacillus rhamnosus on the other hand may cause side effects like gas, bloating, and constipation. The side effects caused are mild and don’t require any medical attention. 

Bacterial strains of Bifidobacterium can cause diarrhea in children and blood infection in the small number of people. 

Another ingredient Caralluma Fimbriata used in Bio X4 for controlling cravings has been shown when taken for a period of 12 weeks. While some mild side effects can include gas, upset stomach, and constipation (2).

Green Tea extract that is 50% EGCG is relatively safe and should cause no side effects (3). 

Digestive Enzymes also includes in Nucific Bio X4 ingredients list. Though they are usually safe and can aid digestion, side effects such as nausea, diarrhea, and abdominal cramps can be seen in a few individuals.

Bromelain is safe as per the dose. However, some side effects occurring due to its use can include diarrhea, stomach upset, and rapid heartbeat. 

Overall, Nucific X4 should be safe for healthy individuals and most Bio X4 side effects don’t need any medical attention. 

Ingredients In Bio X4

The Bio X4 combines four proprietary blends to support your gut health, metabolism, and overall digestive health:

  • Digestive Enzyme Blend (43 mg).
  • Weight Management Blend (100mg).
  • Craving Control Blend (166 mg).
  • Probiotic Blend (4 billion CPU/capsule).

These combinations are mixed into each capsule, which is taken with each meal. We’ll look at the ingredients below to see if these blends are effective.

Digestive Enzyme Blend (43 mg)

Enzymes – are essential for proper digestion, and our bodies naturally produce a variety of enzymes, including lipase and amylase (4).

This blend contains the following enzymes including amylase bromelain and lipase an ingredient in digestive enzyme blends in Nucfic Bio X4. To determine whether or not these blends work, we’ll look at the details of these enzymes below.

These three enzymes in Digestive Enzyme Blend are found to be and help break down carbohydrates, proteins, and fats, respectively.


Amylase converts dietary complex carbohydrates into sugars (5). According to research, amylase may help people who have deficiencies as a result of specific illnesses. This Enzyme supplementation therapy has been studied, and mixed results have been shown.


This enzyme can help your body metabolize fats at a faster rate, which can be useful for weight loss. Lipase has a special role in fat absorption by your body. It breaks down fat molecules to get absorbed by your body. 


It is an enzyme most commonly known to ease pain and swelling due to its powerful anti-inflammatory properties. A few common side effects you may experience with the use of Bromelain include stomach upset diarrhea and vomiting. 

Weight management Blend (100mg)

To enhance the weight loss experience the Bio X4 contains EGCG as a part of its weight management blend. EGCG is an extract from green tea known for boosting your metabolism providing more energy and achieve you a slimmer body shape. 

Most studies on EGCG have been inconsistent, still during one study it was found that drinking 434 ml or two cups of green tea is associated with lower body fat and weight loss. 

EGCG also has anti-inflammatory and antioxidant properties and is thus associated with good heart health and brain health. 

A few possible side effects associated with ECGC intake could include dizziness, anemia, and failure of the liver and kidney. 

Craving Control Blend (166mg)

In order to reduce your regular craving, the supplement contains Slimaluma or the Caralluma Fimbriata extract. It is a patented proprietary extract by Gencor mainly used for its property to suppress appetite. 

According to Gencor, Slimaluma has been scientifically researched for benefits such as increased satiety, mood, and weight management.

The appetite-suppressing ability of Slimaluma helps you to consume lesser calories while you are in your weight loss regime. It also can help reduce anxiety and show mood enhancement. 

Similar to most other ingredients used in Bio X4, Caralluma Fimbriata’s side effects are related to the stomach, such as gas, constipation, and stomach pain. However, in most cases, it is mild and not much noticeable. 

Probiotic Blend (4Billion CFU)

This is the most important and critical blend responsible for most properties of Bio X4 as a probiotic supplement. 

This blend contains three strains of Lactobacillus and two strains of  Bifidobacterium 

Lactobacillus Blend

The Lactobacillus strains in the Bio X4 probiotic include L. rhamnosus, L. acidophilus, and L. Plantarum. These probiotic strains can help promote the health of your gut and digestive system. 

L. rhamnosus found in your gut is known for helping with symptoms of IBS, treating diarrhea, and strengthening immunity. A few studies also show that patients who took L. rhamnosus showed significantly more weight loss than placebo. 

L. acidophilus is also useful for digestive disorders and promotes the growth of good bacteria. While L. Plantarum can help with your cardiovascular health.  Animal studies using L. Plantarum have shown it can have weight-reducing and anti-obesity properties. 

Bifidobacterium Blend

Other than the lactobacillus strains Bio X4 has a blend of Bifidobacterium strains containing B. lactis and B. animalis. 

The probiotic B. lactis is used for problems like constipation, IBS, and respiratory tract infection. Some animal studies have also shown B. lactis to reduce weight gain and increase glucose intolerance. 

Bifidobacterium animalis have similar benefits as B. lactis. These bacterial strains are usually considered safe with some side effects like gas and bloating.

How Does Bio X4 Works?

As you know that Nucific Bio X4 is a probiotic supplement it comes with digestive enzymes and probiotics which support the digestive system (6). 

The digestive enzyme blend contains enzymes that assist with proper food digestion which can help with the proper absorption of nutrients. 

In a study, EGCG, which is part of a weight management blend in Nucfic Bio X4, helped in significant weight loss and reduced waist circumference when EGCG was given at a dosage of 856.8 daily, 

But this is not the case with Nucfic Bio X4 because it has 100mg of Green Tea Extract with 50% EGCG, which means that higher doses would not give the same result as shown in the study.

There has been researched that shows that Green Tea Extract, as part of a Weight Management Blend, has metabolism-boosting effects that help in stimulating fat burning and promoting fat breakdown by increasing the number of calories your body burns through thermogenesis (7).

Slimaluma (Caralluma Fimbriata extract) is found in Bio X4 and has the ability to help the body burn stored body fat and promote weight loss. 

A recent study has shown that supplementing with Caralluma Fimbriata extract reduced waist circumference by 2.7cm (approximately 1 inch) compared to the control group.

Bio X4 Benefits

Based on the available evidence/evaluation of Nucfic Bio X4 ingredients, the following is a summary of its available benefits:

  • Increases energy and metabolism/immunity.
  • The digestive enzymes aid in the digestion process.
  • Helps with weight loss.
  • It can aid your carvings
  • It regulates and promotes gut health.

Bio X4: Pros And Cons


  • If you are dissatisfied with Nucfic, you can get a refund within three months.
  • The company is a reliable organization that has been third-party verified.
  • Established research-backed ingredients support its claims of digestion, metabolism, and overall gut health support.
  • According to their product page, this product is Doctor-Developed.


  • Some people may find it costly.
  • Because the formula contains proprietary blends, the dosage amounts are questionable and unknown.
  • Some of the product’s claims are exaggerated due to a lack of research on certain ingredients.
  • It may cause some side effects, but they are minor and are associated with certain ingredients.
  • This probiotic supplement is not available in stores
  • It requires taking one capsule per day, so noticing the benefits will take about 60 days based on the recommended dosage.

Cost And Where To Buy

On the official website, a 30-day supply of Nucific Bio X4 costs $99.00. The only way to save money on this product if you buy it from their website is if you have a coupon code.

It is also available for purchase on Amazon for $59.95, which works out to $0.67/count for a 60-day supply. You can also save 10% by enrolling in the subscribe and save program at a similar price.

There is a money-back guarantee return policy of 90 days.

When it comes to overall product experience, it received a rating of below average or decent. Additionally, the price for Nucfic Bio X4 is on the higher end when compared to other gut health and weight loss supplements.

Bio X4 Side Effects: Conclusion

Looking at the ingredient list and the side effects, it appears that there will be no serious side effects, but you may notice some digestive changes in your routine when you first start using this supplement.

Because digestive enzymes and probiotics aid in the digestion of food, you may find yourself using the restroom more frequently.

There are some things to consider before trying this supplement, such as people with diabetes or compromised immune systems should consult with their doctor before taking it.

Also, you should not try this if you are pregnant or nursing before taking a supplement unless your doctor advises you to.

Aside from that, you may experience some minor side effects from some of the ingredients.

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