Peptiva Side Effects: Pros, Cons, Side Effects, And Dosage

If you haven’t taken or heard of probiotics supplements, there’s a good chance that someone in your life has recommended you because they have skyrocketed in popularity in the last decade for conditions such as mental health, gastrointestinal issues, obesity, and our overall well-being.

However, there are numerous probiotic subspecies, species, and strains to consider in any probiotic-based nutritional supplement, and many supplement companies combine dozens of different probiotics in specific combinations to address specific/particular issues.

That can make it difficult to know or choose which one is best for you, so we found a probiotic supplement called Peptiva Probiotics + Sleep Supports based on our extensive research and after viewing/reading user reviews with these probiotics.

The supplement was created by a doctor and claims to improve your sleep quality through the use of effective probiotic strains and a combination of ingredients. 

In this article, we looked at the supplement’s side effects, its pros, and cons, and tried finding if Peptiva is really worth a buy or not.

Without further ado, let’s get started.

What Is Peptiva?

Peptiva is a probiotic supplement that is designed using 26 Billion CFU of Probiotic strain and claims to help support sleep and aid digestion. 

The probiotic formula works on the action of the core ingredients which include Lactobacillus strains, Bifidobacterium strains, Valerian root, and melatonin. 

Pevptiva probiotic supplement also claims to deal with problems related to intestinal discomfort, bloating, and digestive function in humans. 

It can relax your body just within 30 minutes of taking it. However, to experience digestive benefits, Peptiva may take as long time as 8-10 weeks.

Dr. David Katz, the director, and co-founder of Yale Prevention Research Center holds the credit for manufacturing the groundbreaking prebiotic formula.

Peptiva is specially formulated with the view of nighttime use. When your body replenishes itself during the night, the time is ideal for promoting the colonies of health-promoting bacteria. 

Thus, Peptiva works with the combined action of sleep-promoting ingredients such as GABA and Melatonin. 

Potential Side Effects Of Peptiva

The probiotic supplement Peptiva can have some minor side effects resulting from the use of ingredients and probiotics. 

Mostly probiotic supplements or the bacterial strains they are made up of are safe for the majority of individuals. 

Probiotics are useful bacteria that are already present within your body. For the first few days, it may cause mild side effects such as diarrhea, flatulence, gas, and upset stomach. 

Peptiva works to improve sleep with the help of ingredients like melatonin and PharmaGABA. 

Melatonin sourced exogenously is safe and also tolerable at higher dosages. However, as per reports and studies, it might have little or very mild side effects such as sleepiness, dizziness, nausea, and headache. 

The exogenously sourced melatonin should be avoided by children, breastfeeding, and pregnant women. 

GABA is a neurotransmitter that is used for relaxing your mind and promoting sleep by making it free from stress, fear, and anxiety.  

A few of the side effects reported commonly due to GABA supplementation include headache, upset stomach, sleeplessness, and muscle weakness. 

Thus melatonin and GABA may contribute to the minor Peptiva side effects. 

One of the natural extracts found in Peptiva is Valerian root. This root also finds its common use as a sleep aid, especially in conditions like insomnia. 

Though Valerian root doesn’t commonly show side effects and is fairly safe side effects such as sleeplessness, dizziness, and headache may occur. 

So, we see the majority of ingredients in Peptiva are safe for healthy individuals but some might have chances to show minor side effects.

Few people complained that Peptiva shows them nightmares and makes them wake up late at night. 

Here are a few people’s concerns regarding Peptiva’s side effects as per the reviews. 

“There must be a lot of melatonin in these because they made me so groggy the next day that I couldn’t even function. Had to discontinue use immediately. – Katie M

“All this product did for me was make me bloated and full of gas. I never get bloated so I know it’s the product. I can’t believe that they have the nerve to charge so much money for it. I’m not sleeping any better and I’m groggy most of the day. I wouldn’t mind spending the money if it worked, but it doesn’t. Save your money.” – Amazon Customer

“I felt horrible the next morning like I do when I take an over-the-counter sleeping pill: groggy, depressed. and anxious. OTC Sleeping Pills cost about $10 and the same for Probiotics. Paying $50 for these supplements is absurd. The doctor who is selling you these pills should be barred from practice.” – CAT Ebarbo

Thus, you see that Peptive doesn’t usually have side effects but minor side effects can be seen. We always recommend speaking to your doctor before you plan of consuming any of these.  

Check: Provitalize Side Effects: Is Provitalize a Safe Probiotic?


Peptiva Probiotics contains 26 billion CFUs and uses a proprietary blend of probiotics.

Since this is a proprietary blend, it is challenging to say whether probiotics are present in clinically useful quantities. Five different probiotic strains, two plant extracts, and amino acids are included in the proprietary blend.

These strains and active ingredients include:

  • Lactobacillus acidophilus (ATCC SD6865 and SD6866).
  • Bifidobacterium bifidum (ATCC SD6869).
  • Bifidobacterium animalis subsp. lactis (ATCC SD6870).
  • Lactobacillus rhamnosus (IMC 501).
  • Gamma-Aminobutyric Acid (from PharmaGABA), 100 mg.
  • Melatonin (delayed and immediate release), 1.5 mg.
  • Valerian Root Extract, 50 mg.

Lactobacillus acidophilus (ATCC SD6865 and SD6866)

Lactobacillus acidophilus is the most commonly used probiotic that is used to promote gut health.

Lactobacillus acidophilus is a type of bacteria that enhances gut flora balance, decreases gut inflammation, and enhances gastrointestinal function.

One clinical trial on patients with digestive problems/illness discovered that taking (L. acidophilus) this bacteria twice daily improved bloating symptoms after four weeks.

Bifidobacterium bifidum (ATCC SD6869)

Bifidobacterium bifidum is the most abundant bacteria in the gut microbiota of healthy breastfed infants, plays a significant role in overall health, and has been shown to strengthen your gut (1).

In one randomized trial, it was discovered that patients with IBS symptoms who took either a placebo or a B. bacterium strain for four weeks, once daily, fared significantly better than controls in terms of pain, bloating, digestive issues, and bowel control.

Bifidobacterium animalis subsp. lactis (ATCC SD6870)

Bifidobacterium animalis is a species that has been shown to improve your gut microbiota and overall health by reducing dysbiosis, or a bacterial imbalance in your gut (2).

According to one randomized clinical trial, adults who supplemented with B. lactis UABla-12 for six weeks experienced significant improvements in their quality of life, bowel habits, bloating, and IBS symptoms when compared to those who received a placebo.

Lactobacillus rhamnosus (IMC 501)

Lactobacillus rhamnosus is a bacteria strain found in the human gut that is frequently added to fermented foods.

According to research, the strain is effective in treating diarrhea caused by antibiotics and C. diff colitis, and cancer treatment-related diarrhea (3, 4).

A 2014 clinical trial found that adults who took this probiotic with enriched foods or capsules after 12 weeks experienced reductions in bloating, constipation, and irregular bowel movements. These improvements were seen in comparison to a placebo group.

Check: Pro B Fresh Review: Does The Dental Probiotic Relief Bad Breath?

Gamma-Aminobutyric Acid (from PharmaGABA), 100 mg

GABA is a neurotransmitter and amino acid produced naturally by your brain, GABA reduces the response of your central nervous system to stimulation when it binds to receptors and fosters a calming effect (5).

A 2015 study suggests that taking GABA both alone and in combination with Apocynum venetum leaf extract was found to shorten the time it takes to fall asleep and increase slow wave sleep.

GABA reduces wakefulness while promoting slow-wave sleep (6,7).

Melatonin (delayed and immediate release), 1.5 mg

Melatonin is a naturally occurring hormone in our bodies that regulates our sleep-wake cycle. This is our circadian rhythm, and it is responsible for promoting healthy sleeping habits.

A 2004 study found that taking melatonin reduced the time it took to fall asleep, increased total sleep time, and enhanced sleep quality when compared to a placebo.

Peptiva Probiotics + Sleep Support contains 1.5 mg of melatonin per serving.

Melatonin doses of 1-6 mg have been shown to be most effective for sleep disorders such as insomnia, sleep-related breathing disorders, and other conditions, according to a recent 2019 review.

Valerian Root Extract, 50 mg

Valerian is a herb indigenous to both Asia and Europe. Its roots have been used to promote sleep for at least 2,000 years and appear to work in tandem with GABA (also found in this formulation) to promote restful sleep (8,9).

A meta-analysis of 60 studies and a review of Valerian root discovered that its roots can help improve sleep quality and reduce anxiety.

Peptiva Pros And Cons

Every supplement comes with a few pros and a few cons based on which we make a decision if the product is worth it. 

There are several Pros and cons of Peptiva that users must have in mind before deciding to buy it.

The pros and cons of Peptiva include:

Peptiva Pros

  1. Can help promote quality sleep: The use of sleep-promoting ingredients such as melatonin and GABA helps Peptiva to relieve stress, and anxiety, and promote quality sleep timing.
  2. Flourish healthy gut and the intestine microbiome: Since peptiva is a probiotic supplement it contains various strains of bacteria that can benefit your gut and overall health.
  3. Improve digestive health – The presence of healthy bacteria such as strains of Lactobacillus and Bifidobacterium can help Peptiva to improve your digestive health. It can ease bloating, stomach discomfort, and stomach issues.
  4. Natural ingredients- Most of the ingredients included in Peptiva Probiotics and Sleep Support are natural. Thus, there is very little risk to experience side effects while you take it.
  5. Easily available – Even though Peptiva doesn’t have an official website, the supplement is easily available in third-party stores such as Amazon and GNC.

Peptiva Cons: 

  1. Expensive for a few users: The probiotic supplement is expensive (i.e. $49.99/container) as compared to other probiotics with similar benefits. However, if it shows the results, Peptiva is still a good choice.
  2. Significant Negative Reviews: For many users, the supplement hasn’t shown the expected result. Negative reviews have a significant percentage in the review section. 
  3. Doesn’t have a pleasant odor: Peptiva doesn’t have a good smell, the smell is described as fish-like. 
  4. Limited bacterial range: Peptiva delivers a limited range of bacteria when compared to its alternatives at cheaper prices. 
  5. Disturbed sleep: Even though Peptiva is designed to promote quality sleep, for some it made them wake up during the night and they experienced nightmares more frequently.

Check: UMZU Floracil50 Review: Is This Probiotic Really Effective?

Dosage And Warnings

The dose for Peptiva as directed by the company is one capsule per day. Each container contains 30 capsules that will last up to a month. 

You should take the capsule at least half an hour to one hour before bedtime. It can be taken with or without food. However, we recommend taking the pill with some meals.


Peptiva should not be taken in case: 

  • You are under 18 since no research has been done on its safety in children and adolescents. 
  • If you are pregnant of a breastfeeding mother, Peptiva isn’t recommended. 
  • With people on prescription drugs, Peptiva should only be taken after consulting your doctor. 

Is Peptiva Worth The Money?

Peptiva probiotics sleep support is designed to improve your sleep quality and benefit your digestive system. It doesn’t contain many potentially harmful ingredients. 

The side effects of Peptiva are generally mild such as disturbed sleep, headache, anxiety, and stomach problems.

It contains sleep-inducing ingredients such as melatonin and GABA that should be avoided by pregnant and breastfeeding women.

Besides this Peptiva comes with several pros and cons you should keep in mind. Peptiva is an expensive probiotic supplement when compared with its alternatives.

But it has worked for many people since it helps you relax and get rid of your digestive and stomach discomfort to provide you with a healthy sleep time. 

So if you think nothing works for you to help your stomach problems and provide you good sleep at night, Peptiva might be worth a try. 

That was all for the Peptiva side effects, pros, and cons. Now, we would like to take your thoughts on this supplement. What do you think of Peptiva?

Notify of

Inline Feedbacks
View all comments
Share via
Copy link
Powered by Social Snap